Example evidence answers

These are example CliniAtlas answers to common clinical questions, shown in full so you can see the format: a plain-language synthesis with citations beside supported claims, sources graded by their place in the evidence hierarchy, and honest limitations. Verify as a healthcare professional to ask your own questions against live sources.

• Do GLP-1 receptor agonists reduce cardiovascular events in type 2 diabetes?Yes — a class-level reduction in major adverse cardiovascular events, best established in higher-risk patients.
• What are the benefits and harms of melatonin for insomnia in adults?A small reduction in sleep latency and modest gain in sleep time; CBT-I is first-line, melatonin only weakly recommended.
• Do SGLT2 inhibitors help in heart failure with preserved ejection fraction (HFpEF)?Yes — they reduce heart-failure hospitalisation across the preserved/mildly-reduced EF range; mortality benefit is not established.
• Direct oral anticoagulants vs warfarin in non-valvular atrial fibrillation — which is preferred?DOACs are at least as effective as warfarin with less intracranial bleeding, and are preferred first-line in non-valvular AF.
• Do corticosteroids help in community-acquired pneumonia?In severe CAP requiring intensive care, adjunctive corticosteroids reduce mortality; benefit in non-severe disease is weaker.
• Does vitamin D supplementation prevent fractures in older adults?In generally healthy, non-deficient adults, vitamin D does not reduce fractures; deficient or osteoporotic groups differ.
• How long should dual antiplatelet therapy continue after PCI?12 months is the default after ACS, individualised by bleeding and ischaemic risk; 1 month can suffice in high bleeding risk.
• Does tranexamic acid help in postpartum haemorrhage?Early tranexamic acid reduces death due to bleeding in postpartum haemorrhage; benefit is time-critical (within 3 hours).